Urea cycle regulation by mitochondrial sirtuin, SIRT5
نویسندگان
چکیده
منابع مشابه
Urea cycle regulation by mitochondrial sirtuin, SIRT5
Mammalian sirtuins have diverse roles in aging, metabolism and disease. Recently we reported a new function for SIRT5 in urea cycle regulation. Our study uncovered that SIRT5 localized to mitochondria matrix and deacetylates carbamoyl phosphate synthetase 1 (CPS1), an enzyme which is the first and rate-limiting step of urea cycle. Deacetylation of CPS1 by SIRT5 resulted in activation of CPS1 en...
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Sirtuins are NAD-dependent protein deacetylases that connect metabolism and aging. In mammals, there are seven sirtuins (SIRT1-7), three of which are associated with mitochondria. Here, we show that SIRT5 localizes in the mitochondrial matrix and interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and dispos...
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ژورنال
عنوان ژورنال: Aging
سال: 2009
ISSN: 1945-4589
DOI: 10.18632/aging.100062